Showing posts with label brain plasticity. Show all posts
Showing posts with label brain plasticity. Show all posts

Wednesday, September 25, 2024

Tiny 'brains' found between brain cells

This bulge of brain cells should not be that hard to understand. What we need are tools.

Behold, the physical base of consciousness? NO
Between and around the billions of neurons in the human brain is an equally vital scaffold, the extracellular matrix (ECM).

An interlinked net of proteins and sugars that surrounds brain cells, the ECM is more than simple structural support; changes in the ECM can regulate complex brain functions including memory, learning, and behavior.

Buddha's Brain (Rick Hanson)
But studies of the brain's ECM have been limited by the lack of tools to observe dynamic changes to its structure. Now, a new genetic labeling tool developed by University of Utah Health researchers Dr. Igal Sterin, Ph.D. and Dr. Sungjin Park, Ph.D. has revealed new patterns in brain ECM in mice, including differences in the amount of matrix deposited on different types of neurons.

A major advantage of the tool is that it can detect changes in the ECM over time, giving new insights into how the brain develops.

The research is published in The Journal of Neuroscience.
  • In biology, the extracellular matrix (ECM) [1, 2] also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins, and hydroxyapatite that provide structural and biochemical support to surrounding [brain] cells [called neurons] [3, 4, 5]. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication, and differentiation are common functions of the ECM [6]. More: extracellular matrix
Hacking of the American Mind (How? Dopamine)
The new tool has two main parts -- a protein that binds to the main ingredients of the brain ECM fused to another protein that irreversibly sticks to a variety of synthetic fluorescent dyes.

When scientists introduced the tool into neurons, it bound to the surrounding matrix. They then added a fluorescent dye to make matrix structures visible.

Using this tool, the researchers were able to watch as ECM was deposited over time in cultured rodent brain cells, making out dense clusters of matrix that appeared on only certain neurons and at different times.

Saturday, March 9, 2024

Science: psychedelics heal mind and body

Eric Ralls (Earth via MSN, 3/8/24; Pat Macpherson, Dhr. Seven (eds.), Wisdom Quarterly
But what if my "ego" temporarily dies? Ego-death, it sounds too risky. How would I carry on?
Psychedelic compounds secreted by toad skin greatly improve cognitive functioning (Earth)
.
What would Shiva, the Destroyer, do?
A combination of two psychedelic compounds (entheogenic substances) demonstrated significant efficacy in treating a range of symptoms, including depression, anxiety, and cognitive impairments, in U.S. special operations forces veterans [presumably suffering from severe PTSD due to all of their immoral deception and covert militant activity involving killing and subterfuge].

This novel approach [taking drugs to treat the head and heart] might offer a beacon of hope for many veterans who do not find relief in traditional therapies.

The government tricked me into becoming a killer
Which psychedelic compound was used? The treatment regimen combined two psychedelic drugs.

The first, [Iboga] ibogaine hydrochloride, is sourced from the West African shrub called iboga. The second, [Bufo] 5-MeO-DMT, is a substance secreted from the [Mexican] Colorado River toad.

Both these substances are categorized as Schedule I drugs under the U.S. Controlled Substances Act, a classification reserved for drugs with no current accepted medical use and a high potential for abuse [which is a disgusting abuse of the law as no one abuses these entheogens for mere recreational use because they have the tendency to cure addiction as well as giving life-changing trips].

This research, spearheaded by The Ohio State University (osu.edu), discovered not only alleviation in symptoms of post-traumatic stress disorder (PTSD) [Aha!] but also a noteworthy improvement in cognitive functions related to traumatic brain injury. [Entheogens heal both matters of the heart and body? PTSD is a mental disorder, whereas TBI is physical damage to an organism's brain or cranial contents, such as feeder veins and capillaries.]

The latter finding was especially unexpected and sheds new light on the vast potential of psychedelic treatments.
Unique challenges in treating veterans

I was raped by my C.O. He called it 'friendly fire'
Alan Davis, the lead author and the director of the Center for Psychedelic Drug Research and Education (CPDRE) at Ohio State's College of Social Work, emphasized the unique challenges faced by special operations forces veterans.

"Their routine exposure to traumatic events often results in a mix of problems including traumatic brain injury, which predisposes them to a plethora of mental health challenges," said Davis.

He noted the most "striking results" were the observed improvements in cognitive functioning linked to brain injuries.
  • VIDEO: Psychedelic mushrooms have potential to help Americans overcome numerous ailments: Ashley Troxell (FOX News)
How the study was conducted
Most of the veterans in this study involving psychedelic drugs had been on active duty post the 9/11 tragedy. They sought care for a gamut of issues ranging from memory problems, depression, PTSD to sleep disturbances, fatigue, and anger.

An astounding 86% of these veterans had experienced head injuries, attributing many of their symptoms to these past traumas.

To measure the efficacy [effectiveness] of the treatment, 86 veterans were asked to complete pre-treatment questionnaires that gauged various mental health symptoms.

The treatment protocol involved administering a single oral dose of ibogaine hydrochloride and inhalation doses of 5-MeO-DMT on separate days.

These drug administrations were flanked by preparation and reflection sessions [in consideration of set and setting, which are essential to successful psychedelic experiences].

Therapy results from psychedelic drugs
The results were indeed promising. A month after the treatment, the veterans reported significant improvements in symptoms of PTSD, depression, anger, and insomnia.

Moreover, there was a substantial uptick in their life satisfaction. These benefits remained consistent even at the three- and six-month post-treatment check-ins.

Furthermore, the veterans experienced improvements in disability, post-concussive symptoms, and showcased tremendous growth in psychological flexibility and cognitive function.

The latter, improved cognitive function, piqued Davis's interest. He believes further investigation is needed to discern whether this improvement stems from a reduction in mental health symptoms, biological alterations in the brain's signaling, or a combination of both.

Insightful and mystical experiences reported
Man, it was great. The whole world was peace
Moreover, Davis highlighted the association of psychological flexibility with insightful and mystical experiences induced by psychedelics [which should now be called entheogens, as they are not recreational drugs like LSD but rather shamanic substances inducing life-altering spiritual experiences].

"The higher one's psychological flexibility, the more probable is the reduction or mitigation of one's mental health symptoms," he explained.

Post-treatment feedback also revealed intriguing insights into the veterans' personal experiences. Almost half described their psychedelic experience as the most spiritually significant or psychologically insightful of their lives.

However, a smaller fraction (17.1%) also found it to be the most challenging experience they ever encountered. [Beware the potential for freaking out, panicking, or having a nightmare tour of the dark recesses of the mind and memory banks from this and/or past lives and other dimensions. Set and setting and a good guide are vital elements to include in any treatment.]

To ensure the integrity of their findings, Davis and his team adopted a conservative data analysis approach, accounting for the possibility that non-respondents might not have derived the desired benefits from the treatment.

The positive outcomes of this research emphasize the potential of psychedelic-assisted therapies, particularly for veterans with intricate trauma histories.

This underscores the need to further explore psychedelic therapies in U.S. clinical trials. Notably, Ohio State is already diving deeper into the realm by studying psilocybin-assisted therapy for PTSD treatment among military veterans.

For those keen on delving into the intricate details of this study, it's published in the esteemed American Journal of Drug and Alcohol Abuse.
---
Like what you just read? Subscribe to newsletter for engaging articles, exclusive content, and the latest updates: Check out EarthSnap, a free app by Eric Ralls and Earth.com.

Sunday, August 13, 2023

Science: Born gay? YOU might be a woman

The Babylon Bee, 5/24/22; Real Pride, 6/26/21; CC Liu, Sheldon S. (eds.), Wisdom Quarterly

Signs You Might Be a Woman
(The Babylon Bee) Are YOU a woman? It's hard to tell these days. There's really no way to tell. But watch this well-researched video to find out whether you indeed might be a woman. (Send all complaints and hate mail to Bro Dude, c/o TheBabylonBee.com).


Born This Way: The Science Behind Being Gay (LGBT+ documentary)
(Real Pride - LGBT+ Documentaries) Are some men born gay? In this 2013 documentary, gay filmmaker Bryce Michael Sage explores how same-sex attraction can be compatible with evolution and how it could have survived through generations of history.

This is a winner of multiple awards across international film festivals called Survival of Fabulous seeks to find out how one stayed on the right track if born this way.

Maybe you're a lesbian man. Did you ever think of that? Just say LGBTQ+

ABOUT: Real Pride celebrates the LGBTQIA'LMNNOP+ community around the world with amazing documentaries. Content licensed by Scorpion TV. For more documentaries that celebrate the LGBTQ+ community, subscribe: tinyurl.com/RealPrideChannel

Monday, June 15, 2020

Neuroscience meets Buddhism: Matt Ricard

(Action for Happiness) Matthieu Ricard and Wolf Singer join Mark Williamson for a discussion of Beyond the Self, sharing insights from Buddhism and neuroscience to help us live happier, more compassionate lives. Filmed in front of a large audience in London on Jan. 29, 2018.

There is no "self"
"Self" (atta=soul, ego) is illusory.
Let's do what the Buddha did and move BEYOND the self. But what is the "self," the ego, soul, personality, identity, consciousness? It is an illusion. We can think of it as our body and mind. But most of us will feel it's a lot more our mind (name, consciousness, awareness, memories) and hardly this ever-changing body. "Mind," the Buddha discerned, is what we cling to as self: feelings, perceptions, mental formations, and consciousness. But none of this is enduring, identical, or able to provide fulfillment. It is something, but it is not a self. The gateless gate to enlightenment is the realization that all that we regard as "self" is actually impersonal. What if psychology knew that? What if neuroscience could test that? Former geneticist Matthieu Ricard and Professor Wolf Singer wrote a book merging neuroscience and Buddhism.

Beyond the Self: Conversations Between Buddhism and Neuroscience
Buddhism meet neuroscience
This book examines converging and diverging views on mind, self, consciousness, free will, unconscious, perception, meditation, and other topics.

Buddhism, on the one hand, shares with science the task of examining the mind empirically. It has pursued, for more than two millennia, direct investigation of the mind through penetrating introspection.

Neuroscience, on the other hand, relies on third-person knowledge in the form of observation. In this book, French Buddhist monk Matthieu Ricard, who trained as a molecular biologist, and Prof. Wolf Singer, a distinguished neuroscientist, offer their perspectives on mind, self, consciousness, subconscious, unconscious, free will, epistemology, meditation, and neuroplasticity.

Matthieu Ricard and his dad
Ricard and Singer's wide-ranging conversation is an enlightening and engaging encounter between Buddhism's wealth of experiential findings and neuroscience's abundance of experimental results.

Among many other things, these two good friends discuss
  • the difference between rumination and meditation (rumination is the scourge of meditation, whereas psychotherapy depends on it);
  • the distinction between the contents of awareness and pure awareness;
  • the Buddhist idea (or lack of one) of the unconscious and neuroscience's precise criteria for conscious and subconscious processes; and
  • the commonalities between cognitive behavioral therapy and meditation.
Their views diverge. (Ricard asserts that the third-person approach will never encounter consciousness as a primary experience). And they converge. (Singer points out that the neuroscientific understanding of perception as reconstruction is very like the Buddhist all-discriminating wisdom).

But both keep their vision trained on understanding fundamental aspects of human life. More

Friday, July 19, 2019

Mindfulness meditation at UCLA (video)

UCLAhealth.org; Dhr. Seven, Ananda (Dharma Meditation Initiative), Wisdom Quarterly

MARC (the Mindful Awareness Research Center at the University of California, Los Angeles) is excited to announce that the UCLA Mindful app has now been released for both iOS and Android as “UCLA Mindful” in the app store (iTunes/Google Play).
MARC is a partner of the Norman Cousins Center for Psychoneuroimmunology within the Jane and Terry Semel Institute for Neuroscience and Human Behavior on the UCLA campus. More


Wednesday, August 30, 2017

Happy? Boost dopamine, serotonin, oxytocin!



Increase happiness: boost your endorphin, dopamine, serotonin, and oxytocin levels
Loretta Graziano Breuning Ph.D.
Habits of a Happy Brain shows how to retrain our brain to turn on the endogenous chemicals that make us happy.

Each page offers simple activities that help us understand the roles of our "happy chemicals" -- serotonin, dopamine, oxytocin, and endorphins.

We learn how to build new habits by rerouting the electricity in our brains to flow down new pathways, making it even easier to trigger these happy chemicals and increase feelings of satisfaction when we need them most.

Universe Inside YouFilled with dozens of exercises that help reprogram the brain, Habits of a Happy Brain shows how to live a happier, healthier life!

Monday, September 24, 2012

How to get your Zombie to kill

Making Manchurian Candidates?
 Phil Stewart (Reuters, "Drug Turns Crime Victims Into Zombies"); Wisdom Quarterly
What does a Manchurian Candidate look like? (indybay.org)
   
There's nothing to fear but fear (and zombies).
Halloween and the Day of the Dead are coming soon, so here's a true-life scary story.
   
BOGOTA, Colombia - The last thing Andrea Fernandez recalls before being drugged is holding her newborn baby on a Bogota city bus. 
   
Police found her three days later, muttering to herself and wandering topless along the median strip of a busy highway. Her face was badly beaten and her son was gone.
   
Fernandez is just one of hundreds of victims every month who, according to Colombian hospitals, are temporarily turned into zombies by a home-grown drug called scopolamine,  which has been embraced by thieves and rapists.

[Expect to see scop' on the dance floor as soon as pushers manage to get ayahuasca, iboga, and the dreaded GLINT into tablet form.]
   
"When I woke up in the hospital, I asked for my baby and nobody said anything. They just looked at me," Fernandez said, weeping. Police believe her son Diego was taken by a gang which traffics in infants.
  
WATCH: To be cool in school Jerri Blank had to stoop to glint (Strangers With Candy)
 
Colorless, odorless, and tasteless, scopolamine is slipped into drinks and sprinkled onto food. Victims become so docile that they have been known to help thieves rob their homes and empty their bank accounts. Women have been drugged repeatedly over days and gang-raped or rented out as prostitutes.
   
In the case of Fernandez, the mother of three was rendered submissive enough to surrender her youngest child.
  
Most troubling for police is the way the drug acts on the brain. Since scopolamine completely blocks the formation of memories, unlike most date-rape drugs used in the United States and elsewhere, it is usually impossible for victims to ever identify their aggressors.
 
"When a patient (of U.S. date-rape drugs) is under hypnosis, he or she usually recalls what happened.
  
But with scopolamine, this isn't possible because the memory was never recorded," said Dr. Camilo Uribe, the world's leading expert on the drug. Scopolamine has a long, dark history in Colombia dating back to before the Spanish conquest. 
   
Legend has it that Colombian Indian tribes used the drug to bury alive the wives and slaves of fallen chiefs so that they would quietly accompany their masters into the afterworld.
  
Nazi "Angel of Death" Joseph Mengele experimented on scopolamine as an interrogation drug. And scopolamine's sedative and amnesia-producing qualities were used by mothers in the early 20th century to help them through childbirth.
  
Finding the drug in Colombia these days is not hard.
  
How to react to fear of secret-zombie agents and operatives? Buy a kit? (Examiner).
   
The tree which naturally produces scopolamine grows wild around the capital and is so famous in the countryside that mothers warn their children not to fall asleep below its yellow and white flowers. 
  
The tree is popularly known as the "borrachero," or "get-you-drunk," and the pollen alone is said to conjure up strange dreams.
  
"We probably should put some sort of fence up," jokes biologist Gustavo Morales at Bogota's botanical gardens, eyeing children playing with borrachero seeds everywhere. "If you ate a few of those, it would kill you."
  
Although scopolamine can be easily extracted from the seeds, experienced criminals hardly ever bother with them, police say.
   
Pure, cheap scopolamine is brought across the border from neighboring Ecuador, where the borrachero tree is harvested for medical purposes, Uribe said. The alkaloid is used legally in medicines across the world to treat everything from motion sickness to the tremors of Parkinson's disease.
 
The use of scopolamine by criminals appears to be confined to Colombia, at least for now, and it's not clear why the drug is such a rampant problem in Colombia. Some analysts blame it on a culture of crime in the Andean nation, home to the world's largest cocaine and kidnapping industries, not to mention Latin America's longest-running [CIA-sponsored] guerrilla war.
  
There are so many scopolamine cases that they usually don't make the news unless particularly bizarre. One such incident involved three young Bogota women who preyed on men by smearing the drug on their breasts and luring their victims to take a lick.
   
Losing all willpower, the men readily gave up their bank access codes. The breast-temptress thieves then held them hostage for days while draining their accounts.
   
The U.S. Embassy in Bogota takes scopolamine very seriously and offers staff tips on how avoid being drugged. One piece of advice may seem obvious: Don't let your drinks out of your sight when at a Bogota bar or nightclub.
  
Still, at least three visiting U.S. government employees here have been drugged and robbed over the past two years. Other American victims from time to time appear at the embassy seeking help, still shaking off a scopolamine hangover.
 
"I remember one case; an American reported being drugged," an embassy official said. "He says to his doorman, 'Why did you let them walk out with my stuff.' The doorman says, 'Because you told me to.'"

Wednesday, August 31, 2011

The CIA has us constantly brainwashed

Daniel Brandt (NameBase NewsLine, No. 17, April-June 1997)
Obama "authorizes" CIA to destabilize foreign government (rawstory.com)

Journalism and the CIA: The Mighty [Organ]
Alongside those Greek morality plays and biblical injunctions, we are also reminded by history itself that the use of unethical means to achieve a "worthy end" can be self-destructive. Power, by definition, is isolated from the correcting signals of external criticism.

Or perhaps the feeling of fighting "evil" fits so comfortably, that it is difficult to shed even after objective circumstances change.

The history of U.S. intelligence since World War II follows both patterns. The Office of Strategic Services (OSS), the CIA's predecessor, had jurisdiction over wartime covert operations and propaganda in the fight against fascism.
OSS chief William Donovan recruited heavily among social and academic elites. When the CIA was launched in 1947 at the beginning of the Cold War, these pioneers felt that they had both the right and the duty to secretly manipulate the masses for the greater good.

OSS veteran Frank Wisner ran most of the early peacetime covert operations as head of the Office of Policy Coordination. Although funded by the CIA, OPC was not integrated into the CIA's Directorate of Plans until 1952, under OSS veteran Allen Dulles.

Both Wisner and Dulles were enthusiastic about covert operations. By mid-1953 the department was operating with 7,200 personnel and 74 percent of the CIA's total budget. More

Tuesday, July 5, 2011

Jane McGonigal: Buddhist Geeks Conference

Buddhist Geeks.com

Jane McGonigal has been announced as the latest speaker to be added to the line-up for Buddhist Geeks | The Conference. Jane is one of the world’s leading healing-game designers and digital thinkers and was a sensation at last year’s TED. Her talk was ranked as one of the most engaging they’ve ever had. Jane’s new book is called Reality is Broken. Her work and ideas are available on her website.


Friday, February 18, 2011

"Jane the Concussion Slayer" (brain healing)



Could Gaming Ever Be Good For Us?
The average American kid will have spent 10,000 hours playing games by the time s/he turns 21. That's as much time as one has spent in school. Researcher Jane McGonigal, author of Reality is Broken: Why Games Make Us Better and How They Can Change the World, appeared on the public radio program "Science Friday" today [Feb. 18, 2011] to explain how we might make real life more "gameful." It can fulfill need that reality does not. Gaming need not be escapist, she demonstrates. Sometimes it can be quite "returnist." Life can often be made better by making it more like a "game," defined as an "unnecessary obstacle we choose to overcome." She invented "Jane the Concussion Slayer" to restore brains after head traumas. More>>

Friday, July 31, 2009

Brain's potential explained by big new idea

(LiveScience.com) Different species and individuals have limits as to what they can learn. For instance, you can't teach your dog to read. But what sets these boundaries? According to a new hypothesis, components of an organism's brain cortex may help determine how well that organism, be it dog, monkey or human, learns and improves its cognitive skills.

The cortex is your brain's outer layer, the exterior part you can see if you look at a picture of the whole organ. The new idea posits that small sets of neuronal cells in the cortex, called cortical modules, determine our "cognitive plasticity," that is, our capacity to learn new ways of thinking, or improve upon old ones.

"What [constrains] an individual organisms' ability to learn cognitive skills is essentially the diversity and number of [cortical] modules they have," said Eduardo Mercado III, a psychologist at the University at Buffalo in New York. "So, if you think about it like a set of Legos, if you have more Legos, you can build a wider variety of things."

Quality, not size, matters: These cortical modules are very spatially distinct, like circles in a honeycomb-pattern layered over a brain, Mercado said. More>>

Monday, February 23, 2009

Healing Tones

This piece of music incorporates tones from the full 12 Solfeggio frequency scale. The throat or overtone singing featured on this track is performed by Stian (a.k.a. "stingndr" on YouTube).

There is also Theta brainwave entrainment technology in this track by unisontherapy.com.

The Solfeggio frequencies are from a musical scale used in ancient music, chants, and religious ceremonies that were lost for many centuries. The Solfeggio scale and its chants and frequencies or tones were believed to convey spiritual blessings and transformation when played and sung in harmony.

One of the most interesting Solfeggio frequencies is 528 Hz. Genetic biochemists, according to Dr. Len Horowitz and Dr. Joseph Puleo, suggest this frequency is the repair frequency for damaged DNA. Therefore, 528 Hz is one of the main focus frequencies on this track.

There are nine main Solfeggio frequencies. But it is the six initial tones that many have suggested are of the most benefit. Individual beliefs notwithstanding, as each note has a different tuning from the conventional musical scale, these tones can provide a new stimulus to the mind and physical system.

It has recently been accepted by some scientists that just providing the brain with new input has many benefits in relation to brain plasticity and keeping the mind young, healthy, and activated. As the mind becomes healthy, the physical body also reaps rewards.

The following is a list of some of the Solfeggio Hz and their benefits.

  • 396 Hz - Releasing emotional patterns and the liberation from guilt and fear.
  • 417 Hz - Breaking up crystallized emotional patterns and facilitating change.
  • 528 Hz - "DNA integrity" transformation, love, and miracles.
  • 639 Hz - Whole brain quadrant interconnectedness, connecting relationships.
  • 741 Hz - Intuitive states, non-linear knowing, and awakening intuition.
  • 852 Hz --Unconditional love and returning of spiritual order.

The 12 Solfeggio tones follow a mathematical pattern. They increase by 111 Hz each note.

...63 Hz
.174 Hz
.285 Hz
.396 Hz
.417 Hz
.528 Hz
.639 Hz
.741 Hz
.852 Hz
.963 Hz
1174 Hz
1285 Hz